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Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function

Congratulations to Dr. Xiaojie Ma and Frank Dyka on the publication of “Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function,” which appears in the February issue of Frontiers in Neuroscience. Long-and middle-wavelength cone photoreceptors, which are responsible for our visual…

International Symposium on Retinal Degeneration

The University of Florida was well represented at the twentieth meeting of the International Symposium on Retinal Degeneration held in Torremolinos, Spain. Attending this meeting were faculty members Cristhian Ildefonso, Ekaterina Lobanova, and Clay Smith along with PhD candidate Raela Ridley who all presented on their research to develop treatments…

Dr. Eric Pierce Grand Rounds Guest Speaker on 12/1

Dr. Pierce’s research program is focused on improving our understanding of the genetic causality of inherited retinal degenerations (IRDs) and developing genetically informed therapies for these disorders.  His work has led to the identification of several IRD disease genes, helped highlight the importance of non-coding mutations in IRDs, and…

Use of AAV-expressed M013 protein as an anti-inflammatory therapeutic

Congratulations to Dr. Cristhian Ildefonso on his patent “Use of AAV-expressed M013 protein as an anti-inflammatory therapeutic.” Abstract Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful…

Maturation of synaptic ribbons and synaptogenesis occur after CaBP4 gene augmentation therapy

Congratulations to Dr. William Hauswirth on the publication of “Maturation of synaptic ribbons and synaptogenesis occur after CaBP4 gene augmentation therapy,” which appears in the June edition of Investigative Ophthalmology and Visual Science. Abstract Purpose : Widespread immaturity of photoreceptor synaptic ribbons has been described resulting from several genetic mutations that involve calcium…

A clinically viable approach to restoring visual function using optogenetic gene therapy

Congratulations to Dr. Hauswirth on the publication of “A clinically viable approach to restoring visual function using optogenetic gene therapy,” which appears in the May edition of Molecular Therapy  Methods and Clinical Development. Summary: Optogenetic gene therapies offer a promising strategy for restoring vision to patients with retinal degenerative diseases,…